Topic: Ball mill

Author(s): Dominik Lungerich, Clément Cabanetos, Jongseong Park, Sol Lee and Orein F. Jafter.
A general calculation method for traversing synthetic protocols derived from mixer or planetary ball mills; finding the point impact energy Eimpact of a single collision between the ball and the molecules, and the cumulative energy Etotal, which is transferred to the reaction mixture during the whole milling process.

Author(s): Evelina Colacino, Gandrath Dayaker, Alain Morère and Tomislav Friščić.
This education article describes a solvent-free mechanochemical synthesis in an undergraduate chemistry teaching laboratory. As a model reaction, the experiment addresses the catalytic mechanochemical synthesis of a small library of sulfonylureas, including a known active pharmaceutical ingredient, tolbutamide.