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Mechanochemical Methods for Amide Bond Formation
This review presents a comprehensive account of mechanochemical methods for amide bond formation.
Topic: Amides
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Protecting-group-free mechanosynthesis of amides from hydroxycarboxylic acids: application to the synthesis of imatinib
Mechanochemical amide coupling enables the efficient synthesis and functionalisation of amides, including the first mechanochemical synthesis of imatinib.
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Mechanochemical C–N bond-forming reactions and their application in pharmaceutical synthesis
Author: Tatsiana Nikonovich.
This dissertation expands the current mechanochemical synthetic toolbox by introducing novel C–N bond-forming transformations that address the limitations of existing protocols and present practical applications in API synthesis.