Mechanochemical kilogram-scale synthesis of rac-ibuprofen:nicotinamide co-crystals using a drum mill
This study pioneers the use of a drum mill for pharmaceutical co-crystal synthesis, using rac-ibuprofen:nicotinamide as a representative example.
Topic: Ibuprofen-nicotinamide
Filter by:
Results
Papers
Kinetics of the mechanically induced ibuprofen–nicotinamide co-crystal formation by in situ X-ray diffraction
This paper shows how time-resolved in situ powder X-ray diffraction and kinetic modelling provide mechanistic insight into mechanochemical reactions.
Papers
Utilizing an attritor mill for solvent-free mechanochemical synthesis of rac-ibuprofen:nicotinamide co-crystals
This paper presents a more sustainable, solvent-free mechanochemical process for synthesizing rac-ibuprofen:nicotinamide (IBU:NIC) co-crystals.
Papers
Scalability of Pharmaceutical Co-Crystal Formation by Mechanochemistry in Batch
This paper reports the use of mechanochemical processes in batch to prepare kilogram-scale of Ibuprofen-Nicotinamide co-crystal in an industrial eccentric vibration mill.
Lab protocols
Laboratory Protocol CAU2 Course: Mechanochemistry as an outstanding route for a greener chemistry
Author: Franziska Emmerling
Laboratory protocol for a lecture on mechanochemistry, designed for regular use with MSc and BSc students.