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This work investigates the scale-up of paracetamol-oxalic acid cocrystals using a range of milling technologies.
Vânia André presents the role of IST-ID within IMPACTIVE, partner focused on multicomponent systems and solid-state characterisation.
This study pioneers the use of a drum mill for pharmaceutical co-crystal synthesis, using rac-ibuprofen:nicotinamide as a representative example.
This paper shows how time-resolved in situ powder X-ray diffraction and kinetic modelling provide mechanistic insight into mechanochemical reactions.
This paper presents a more sustainable, solvent-free mechanochemical process for synthesizing rac-ibuprofen:nicotinamide (IBU:NIC) co-crystals.
This paper reports the use of mechanochemical processes in batch to prepare kilogram-scale of Ibuprofen-Nicotinamide co-crystal in an industrial eccentric vibration mill.
Author: Franziska Emmerling
Lecture on mechanochemistry for MSC and BSC students on a regular basis.
Author(s): Michele Prencipe, Paolo P. Mazzeo and Alessia Bacchi.
The prediction of the phase behaviour of a mixture of solid components when they come into contact is of high interest in fast growing research fields such as mechanochemistry and deep eutectic solvents (DESs). This paper provides a friendly predictive tool (PoEM, i.e. Predictor of Eutectic Mixtures), along with some guidelines and quantitative references, to quickly estimate the variation in the melting point due to the mixture of reactants for a mechanochemical process.