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Soft-Mechanochemistry: Mechanochemistry Inspired by Nature
This feature article discusses some examples of soft-mechanochemistry processes encountered in nature.
Mechanochemistry: Looking back and ahead
This article reviews the history of mechanochemistry and explores how digitalisation, robotics and AI could improve its reproducibility and scalability.
Safe and Sustainable by Design (SSbD) Synthesis of Food and Personal Care Ingredients by Mechanochemistry
This paper studies the preparation of perillartine and N-tert-butyl-α-phenylnitrone (PBN) by vibrating and planetary ball-milling.
Structurally similar, functionally different: Impact of coformer positional isomerism on co-amorphous enzalutamide
This paper investigates the effect of positional isomerism on the coamorphous formation and associated physicochemical properties.
Systematic Scale-Up of Mechanochemical Paracetamol–Oxalic Acid Cocrystal Synthesis across Multiple Milling Technologies
This work investigates the scale-up of paracetamol-oxalic acid cocrystals using a range of milling technologies.
Sustainable Beckmann Rearrangement using Bead-Milling Technology: The Route to Paracetamol
This paper reports the first application of bead-mill technology (Dyno®-mill) for the sustainable mechanochemical synthesis of Paracetamol.
Kinetics of the mechanically induced ibuprofen–nicotinamide co-crystal formation by in situ X-ray diffraction
This paper shows how time-resolved in situ powder X-ray diffraction and kinetic modelling provide mechanistic insight into mechanochemical reactions.
Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients
This paper extensively studies three different reaction types at multi-gram scale by resonant acoustic mixing (RAM).
Utilizing an attritor mill for solvent-free mechanochemical synthesis of rac-ibuprofen:nicotinamide co-crystals
This paper presents a more sustainable, solvent-free mechanochemical process for synthesizing rac-ibuprofen:nicotinamide (IBU:NIC) co-crystals.
Mechanochemical Methods for Amide Bond Formation
This review presents a comprehensive account of mechanochemical methods for amide bond formation.