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Safe and Sustainable by Design (SSbD) Synthesis of Food and Personal Care Ingredients by Mechanochemistry

This paper studies the preparation of perillartine and N-tert-butyl-α-phenylnitrone (PBN) by vibrating and planetary ball-milling.

Papers

Kinetics of the mechanically induced ibuprofen–nicotinamide co-crystal formation by in situ X-ray diffraction

This paper shows how time-resolved in situ powder X-ray diffraction and kinetic modelling provide mechanistic insight into mechanochemical reactions.

Papers

Multigram-Scale Organic Synthesis by Resonant Acoustic Mixing: Application to the Sustainable Preparation of Active Pharmaceutical Ingredients

This paper extensively studies three different reaction types at multi-gram scale by resonant acoustic mixing (RAM).

Papers

Utilizing an attritor mill for solvent-free mechanochemical synthesis of rac-ibuprofen:nicotinamide co-crystals

This paper presents a more sustainable, solvent-free mechanochemical process for synthesizing rac-ibuprofen:nicotinamide (IBU:NIC) co-crystals.

Papers

Mechanochemical Methods for Amide Bond Formation

This review presents a comprehensive account of mechanochemical methods for amide bond formation.

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